NCCIH Workshop 2020: Exploring the Mechanisms Underlying Analgesic Properties of Minor Cannabinoids and Terpenes

9:45-9:50 a.m. | Welcome From the National Center for Complementary and Integrative Health (NCCIH)

  • David Shurtleff, Ph.D., Deputy Director, NCCIH

9:50-10:00 a.m. | Meeting Overview and Goals

  • Emmeline Edwards, Ph.D., Director, NCCIH Division of Extramural Research

10:00-11:00 a.m. | Data Blitz Presentations on the Nonclinical Studies Funded by NCCIH Cannabinoids and Pain Funding Opportunity Announcements

  • Sara Jane Ward, Ph.D., Temple University of the Commonwealth, “Analgesic Efficacy of Single and Combined Minor Cannabinoids and Terpenes
  • Yu-Shin Ding, Ph.D., New York University School of Medicine, “Identifying the Mechanisms of Action for CBD on Chronic Arthritis Pain
  • Andrew D. Ellington, Ph.D., University of Texas at Austin, “Synthetic Biology for the Chemogenetic Manipulation of Pain Pathways
  • Cassandra L. Quave, Ph.D., Emory University, “Mechanistic Studies on Analgesic Effects of Terpene Enriched Extracts From Hops
  • David Sarlah, Ph.D., University of Illinois, “Systematic Investigation of Rare Cannabinoids With Pain Receptors
  • Jenny L. Wiley, Ph.D., Research Triangle Institute, “Minor Cannabinoids and Terpenes: Preclinical Evaluation as Analgesics
  • Zhigang He, Ph.D., B.M., Boston Children’s Hospital/Harvard Medical School, “Mechanism and Optimization of CBD-Mediated Analgesic Effects

Q & A Session on Nonclinical Studies

Moderator: Inna Belfer, M.D., Ph.D., NCCIH

11:00-11:15 a.m. | Break

11:15 a.m.-Noon | Data Blitz Presentations on the Clinical Studies Funded by NCCIH Cannabinoids and Pain Funding Opportunity Announcements

  • Rajiv Radhakrishnan, M.B.B.S., M.D., Yale School of Medicine, “Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
  • Deborah Yurgelun-Todd, Ph.D., University of Utah, “Exploring the Mechanisms Underlying the Analgesic Effect of Cannabidiol Using Proton Magnetic Resonance Spectroscopy
  • Judith Hellman, M.D., University of California, San Francisco, “Neuro-Immune Mechanisms of Minor Cannabinoids in Inflammatory and Neuropathic Pain
  • Ziva D. Cooper, Ph.D., University of California, Los Angeles, “Analgesic and Subjective Effects of Terpenes Administered Alone and in Combination With THC: Potential THC- and Opioid-Sparing Effects of Myrcene and β-Caryophyllene
  • Richard E. Harris, Ph.D., University of Michigan at Ann Arbor, “Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee

Q & A Session on Clinical Studies

Moderator: Angela Arensdorf, Ph.D., NCCIH

Noon-1:00 p.m. | Break

1:00-1:30 p.m. | Keynote Presentation (Introduction by David Shurtleff, Ph.D., NCCIH)

Cannabis Research in Canada: Opportunities, Risks, and Lessons Learned

Mark A. Ware, M.B.B.S., MRCP(UK), M.Sc., Chief Medical Officer, Canopy Growth Corporation, Canada; Associate Member, McGill University

1:30-1:45 p.m. | Q & A Session for Keynote Speaker

Moderator: Emmeline Edwards, Ph.D., NCCIH

1:45-2:30 p.m. | Panel Discussion on Gaps and Future Directions

  • Inna Belfer, M.D., Ph.D., NCCIH
  • Roger Little, Ph.D., National Institute on Drug Abuse (NIDA)
  • Jeffrey White, M.D., National Cancer Institute (NCI)
  • Qi-Ying Liu, M.D., M.Sci., National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  • Smriti Iyengar, Ph.D., National Institute of Neurological Disorders and Stroke (NINDS)
  • Mi Hillefors, M.D., Ph.D., National Institute of Mental Health (NIMH)
  • Dominic Chiapperino, Ph.D., Food and Drug Administration (FDA)
  • Terrence L. Boos, Ph.D., Drug Enforcement Administration (DEA)
  • Robert Walsh, R.A.C., NIDA Drug Supply Program

2:30-3:00 p.m. | Q & A Session for the Panelists

Moderator: David Shurtleff, Ph.D., NCCIH

3:00 p.m. | Adjournment